From the Rhone Canal to Sète, the Canal du Rhône au Rhin is one of the important watershed canals of the French waterways, connecting the Rhine to the Saône and the Rhône and thereby the North Sea and the Mediterranean.

In Avene, the first Hydrotherapy Centre was built in 1743 near the Sainte-Odile spring. The vocation of Avène has never changed: The Hydrotherapy Centre is entirely dedicated to dermatology.